pentobarbital will decrease the level or effect of dasatinib ort affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Skärm.pentobarbital will decrease the level or effect of lumefantrine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with stark CYP3A4 inducers can result in decreased seru